Issue 24, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Dilithiation of arenetricarbonylchromium(0) complexes with enantioselective quench: application to chiral biaryl synthesis

Yen-Ling Tan,a   Andrew J. P. White,b   David A. Widdowson,*a   René Wilhelma  and  David J. Williamsb  

* Corresponding authors

a Department of Chemistry, Imperial College of Science, Technology and Medicine, London, UK
E-mail: d.widdowson@ic.ac.uk
Fax: +44(0)2075945804
Tel: +44(0)2075945779

b Chemical Crystallography Laboratory, Imperial College of Science, Technology and Medicine, London, UK

Abstract

Dilithiation of methoxymethoxyarenetricarbonylchromium complexes with 2.5 equiv. of butyllithium and 6 equiv. of (−)-sparteine followed by enantioselective electrophilic quench gave the planar chiral (R)-complexes in up to 95% ee. This technique was applied to the synthesis of the chromium complexes of biaryl analogues 7 of actinoidinic acid.

Graphical abstract: Dilithiation of arenetricarbonylchromium(0) complexes with enantioselective quench: application to chiral biaryl synthesis

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Article information

DOI
https://doi.org/10.1039/B108807F
Article type
Paper
Submitted
28 Sep 2001
Accepted
29 Oct 2001
First published
27 Nov 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 3269-3280

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Dilithiation of arenetricarbonylchromium(0) complexes with enantioselective quench: application to chiral biaryl synthesis

Y. Tan, A. J. P. White, D. A. Widdowson, R. Wilhelm and D. J. Williams, J. Chem. Soc., Perkin Trans. 1, 2001, 3269 DOI: 10.1039/B108807F

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