Issue 2, 2001
From the journal:

Lab on a Chip

The aldol reaction of silyl enol ethers within a micro reactor

Charlotte Wiles,a   Paul Watts,a   Stephen J. Haswell*a  and  Esteban Pombo-Villarb  

* Corresponding authors

a Department of Chemistry, Faculty of Science and the Environment, University of Hull, Cottingham Road, Hull, UK
E-mail: s.j.haswell@hull.ac.uk
Fax: +44 (0)1482 466416
Tel: +44 (0)1482 465475

b Nervous Systems Research, WSJ-386.07.15, Novartis Pharma Ltd., Basel, Switzerland

Abstract

We have demonstrated the use of silyl enol ethers in the aldol reaction within a micro reactor. Quantitative conversion of the silyl enol ether to a β-hydroxyketone was observed in a 20 min period compared to traditional batch systems, where quantitative yields were only obtained when extended reaction times of 24 h were employed.

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Article information

DOI
https://doi.org/10.1039/B107861E
Article type
Communication
Submitted
31 Aug 2001
Accepted
15 Oct 2001
First published
06 Nov 2001

Lab Chip, 2001,1, 100-101

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The aldol reaction of silyl enol ethers within a micro reactor

C. Wiles, P. Watts, S. J. Haswell and E. Pombo-Villar, Lab Chip, 2001, 1, 100 DOI: 10.1039/B107861E

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