Uncatalysed reactions in water: Part 2. Preparation of 3-carboxycoumarins

Raimondo Maggi; Franca Bigi; Silvia Carloni; Alessandro Mazzacani; Giovanni Sartori

doi:10.1039/B101822C

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Uncatalysed reactions in water: Part 2.Part 1: ref. 1. Preparation of 3-carboxycoumarins

Raimondo Maggi,*^a Franca Bigi,^a Silvia Carloni,^a Alessandro Mazzacani^a and Giovanni Sartori^a

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* Corresponding authors

^a Dipartimento di Chimica Organica e Industriale dell′Università, Parco Area delle Scienze 17A, Parma, Italy.
E-mail: raimondo.maggi@unipr.it

Abstract

A simple, efficient and environmentally friendly procedure has been developed for the reaction of Meldrum’s acid with salicylaldehydes. 3-Carboxycoumarins 5 were synthesised in high yields (78–96%) and excellent selectivities (95–98%) by carrying out the reaction in water at reflux for 10 h, avoiding the addition of any catalyst.

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Article information

DOI: https://doi.org/10.1039/B101822C
Article type: Paper
Submitted: 26 Feb 2001
First published: 27 Jun 2001

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Green Chem., 2001,3, 173-174

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