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Issue 1, 2001
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Organic reaction in water. Part 5. Novel synthesis of anilines by zinc metal-mediated chemoselective reduction of nitroarenes

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Abstract

Nitroarenes can be reduced in high yields to the corresponding anilines using zinc metal and NH4Cl in water without any organic solvent at 80 °C with a simple procedure at low cost. The procedure is powerful enough to reduce sterically hindered 2,6-dimethylnitrobenzene and is chemoselective for nitro groups; ester, amide and halide substituents on aromatic rings are unaffected.

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Publication details

The article was received on 12 Oct 2000 and first published on 22 Jan 2001


Article type: Paper
DOI: 10.1039/B008219H
Citation: Green Chem., 2001,3, 37-38
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    Organic reaction in water. Part 5. Novel synthesis of anilines by zinc metal-mediated chemoselective reduction of nitroarenes

    T. Tsukinoki and H. Tsuzuki, Green Chem., 2001, 3, 37
    DOI: 10.1039/B008219H

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