Jump to main content
Jump to site search

Issue 1, 2001
Previous Article Next Article

Getting into shape: Conformational and supramolecular landscapes in small biomolecules and their hydrated clusters

Author affiliations

Abstract

The last few years have seen a very rapid growth in understanding the influence of non-bonded, particularly hydrogen-bonded interactions, on the shapes and conformations of flexible molecules, including those of pharmacological or biological importance, and of the supramolecular structures of their hydrated clusters. This has come about through the combination of a wide range of newly developed spectroscopic strategies, many of which are laser-based, coupled with powerful and widely available ab initio codes for structural computation. The consequent rapid growth of a new link between the worlds of chemistry and biophysics is surveyed in a review which introduces the range of present strategies, their origins, and their application to studies of neutrotransmitters, amides and peptides, amino acids and nucleic acid bases. It concludes with a prospectus for the future.

Back to tab navigation

Publication details

The article was received on 12 Oct 2000, accepted on 14 Nov 2000 and first published on 13 Dec 2000


Article type: Invited Article
DOI: 10.1039/B008225M
Citation: Phys. Chem. Chem. Phys., 2001,3, 1-18
  •   Request permissions

    Getting into shape: Conformational and supramolecular landscapes in small biomolecules and their hydrated clusters

    E. G. Robertson and J. P. Simons, Phys. Chem. Chem. Phys., 2001, 3, 1
    DOI: 10.1039/B008225M

Search articles by author

Spotlight

Advertisements