Issue 24, 2001
From the journal:

Chemical Communications

A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and protein binding†

Dimitri Messeri,a   Mark P. Lowe,a   David Parker*a  and  Mauro Bottab  

* Corresponding authors

a Department of Chemistry, University of Durham, South Road, Durham, UK
E-mail: david.parker@durham.ac.uk

b Dipartimento di Scienze e Tecnologie Avanzate, Università del Piemonte Orientale, “Amedeo Avogadro” Corso Borsalino 54, Alessandria, Italy

Abstract

The high relaxivity of [GdaDO3A]3− (r1p = 12.3 mM−1 s−1, 20 MHz, 298 K, τm = 30 ns) in water is maintained in serum solution because the binding of protein and endogeneous anions, e.g. HCO3−/CO32− is suppressed by electrostatic repulsion.

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Article information

DOI
https://doi.org/10.1039/B108294A
Article type
Communication
Submitted
12 Sep 2001
Accepted
14 Nov 2001
First published
06 Dec 2001

Chem. Commun., 2001, 2742-2743

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A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and protein binding

D. Messeri, M. P. Lowe, D. Parker and M. Botta, Chem. Commun., 2001, 2742 DOI: 10.1039/B108294A

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