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Issue 21, 2001
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Recent advances in solventless organic reactions: towards benign synthesis with remarkable versatility

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Abstract

A paradigm shift away from using solvents in organic synthesis as solventless reactions can lead to improved outcomes, and more benign synthetic procedures, in for example aldol condensation reactions, sequential aldol and Michael addition reactions en route to Kröhnke type pyridines, reactions leading to 3-carboxycoumarins, benzylidenes, 4-aryl-1,4-dihydropyridines and 2-aryl-1,2,3,4-tetrahydroquinazolines, and oligomerisation reactions for the synthesis of cavitands; kinetic considerations for the reaction of two solids can only be explained if a eutectic melt is formed during the reaction.

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Publication details

The article was received on 24 Jul 2001, accepted on 18 Sep 2001 and first published on 17 Oct 2001


Article type: Feature Article
DOI: 10.1039/B106677N
Citation: Chem. Commun., 2001,0, 2159-2169
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    Recent advances in solventless organic reactions: towards benign synthesis with remarkable versatility

    G. W. V. Cave, C. L. Raston and J. L. Scott, Chem. Commun., 2001, 0, 2159
    DOI: 10.1039/B106677N

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