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Issue 19, 2001
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Ready protease-catalyzed synthesis of carbohydrate–amino acid conjugates

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The protease-catalyzed synthesis of amino acid ester–carbohydrate conjugates as glycopeptide analogues has been achieved in a highly regioselective and carbohydrate-specific manner using amino acid vinyl ester acyl donors and minimally or completely unprotected carbohydrate acyl acceptors, which together probed active sites of proteases to reveal yield efficiencies that are modulated by the carbohydrate C-2 substituent, and that may be exploited to allow selective one-pot syntheses.

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The article was received on 10 May 2001, accepted on 06 Jul 2001 and first published on 12 Sep 2001

Article type: Communication
DOI: 10.1039/B104137C
Citation: Chem. Commun., 2001,0, 1908-1909
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    Ready protease-catalyzed synthesis of carbohydrate–amino acid conjugates

    V. Boyer, M. Stanchev, A. J. Fairbanks and B. G. Davis, Chem. Commun., 2001, 0, 1908
    DOI: 10.1039/B104137C

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