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Issue 11, 2001
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Tandem cationic cyclisation–aziridinium ion formation–nucleophilicring opening: new methodology for the stereocontrolled synthesis of substitutedpyrrolidines

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Abstract

A novel tandem cationic cyclisation–aziridinium ion formation–nucleophilic ring opening procedure has been developed which provides powerful new methodology for the stereocontrolled synthesis of a wide variety of substituted pyrrolidines from acyclic precursors. The intermediate bicyclic aziridinium ions can be isolated and their structure has been confirmed by X-ray crystallography.

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Publication details

The article was received on 06 Mar 2001, accepted on 12 Apr 2001 and first published on 11 May 2001


Article type: Communication
DOI: 10.1039/B102124I
Citation: Chem. Commun., 2001,0, 966-967
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    Tandem cationic cyclisation–aziridinium ion formation–nucleophilic ring opening: new methodology for the stereocontrolled synthesis of substituted pyrrolidines

    M. A. Graham, A. H. Wadsworth, M. Thornton-Pett and C. M. Rayner, Chem. Commun., 2001, 0, 966
    DOI: 10.1039/B102124I

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