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Issue 6, 2001
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An unexpected selectivity of a propranolol-derived molecular imprint for tamoxifen

P. D. Martin,*a  T. D. Wilson,a  I. D. Wilsona  and  G. R. Jonesb 
Author affiliations

* Corresponding authors

a Department of Drug Metabolism and Pharmacokinetics, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Cheshire, Macclesfield, UK

b Lennard-Jones Laboratories, School of Chemistry and Physics, Keele University, Staffordshire, UK

Abstract

During the evaluation of molecular imprinted polymers (MIPs) prepared against the drug tamoxifen a propranolol-derived MIP was used as a positive control. Surprisingly the propranolol-derived MIP showed considerable selectivity towards tamoxifen, and was indeed much more selective than the MIP prepared using tamoxifen as the imprint molecule. The consequences of this unexpected, cross reactivity for the use of MIPs in analytical chemistry is discussed.

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Publication details

The article was received on 14 Mar 2001, accepted on 10 Apr 2001 and first published on 09 May 2001


Article type: Communication
DOI: 10.1039/B102424H
Citation: Analyst, 2001,126, 757-759
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    An unexpected selectivity of a propranolol-derived molecular imprint for tamoxifen

    P. D. Martin, T. D. Wilson, I. D. Wilson and G. R. Jones, Analyst, 2001, 126, 757
    DOI: 10.1039/B102424H

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