Issue 5, 2001
From the journal:

Analyst

Investigation of heroin profiling using trace organic impurities

R. B. Myors,*a   P. T. Crisp,b   S. V. Skopeca  and  R. J. Wellsa  

* Corresponding authors

a Australian Government Analytical Laboratories, Research and Development Section, PO Box 385, Pymble, NSW, Australia

b Chemical Engineering and Industrial Chemistry, University of New South Wales, Sydney, NSW, Australia

Abstract

The acidic and neutral impurities in heroin samples (46 Purified South-East Asian (PSEA) and 8 non-PSEA samples) were analysed using gas chromatography. Mass spectral detection allowed the construction of a comprehensive library of over 649 impurities. A variety of statistical procedures were used to select 70 viable profiling parameters. Cluster analyses were used to investigate the similarities between samples using organic parameters. A blended PSEA profile was constructed for comparison with samples of unknown origins. Resolution between samples of PSEA/non-PSEA origins was demonstrated with a selection of 25 (18 continuous and 7 dichotomised) discriminating factors. Several predictive logistic models were created using up to 18 parameters, explaining 85–100% of the variation in the experimental data.

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Article information

DOI
https://doi.org/10.1039/B009093J
Article type
Paper
Submitted
13 Nov 2000
Accepted
07 Mar 2001
First published
20 Apr 2001

Analyst, 2001,126, 679-689

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Investigation of heroin profiling using trace organic impurities

R. B. Myors, P. T. Crisp, S. V. Skopec and R. J. Wells, Analyst, 2001, 126, 679 DOI: 10.1039/B009093J

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