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Issue 24, 2000
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HYDRA: A novel hydroxy and amine functionalised resin synthesised by reductive amination of PEG aldehyde and a polyamine

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Abstract

A chemically inert poly(ethylene glycol) (PEG)-based resin was synthesised by reductive amination of a mixture of mono- and dialdehyde PEG1500 and the branched cross-linker tris(2-aminoethyl)amine. This unique concept of resin polymerisation yields a polar resin with two functionalities present (OH and NH). The resin loading could be tuned between 0.33 and 0.80 mmol OH per gram and 0.88 and 0.24 mmol NH per gram by varying the monomer composition in the polymerisation mixture. The resin was found to exhibit excellent swelling properties in a broad range of solvents, and was stable towards strongly acidic and basic conditions for weeks. Furthermore, both an octa- and a decapeptide were successfully assembled independently on the different functionalities. In addition, the resin was shown to be fully permeable to a 27 kDa protease.

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Publication details

The article was received on 04 Sep 2000, accepted on 29 Sep 2000 and first published on 09 Nov 2000


Article type: Paper
DOI: 10.1039/B007141M
Citation: J. Chem. Soc., Perkin Trans. 1, 2000,0, 4258-4264
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    HYDRA: A novel hydroxy and amine functionalised resin synthesised by reductive amination of PEG aldehyde and a polyamine

    T. Groth, M. Grøtli, W. D. Lubell<small xmlns="http://www.rsc.org/schema/rscart38"> <sup>1</sup> </small>, L. P. Miranda and M. Meldal, J. Chem. Soc., Perkin Trans. 1, 2000, 0, 4258
    DOI: 10.1039/B007141M

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