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Issue 21, 2000
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Tetrahydrofuran amino acids—versatile building blocks for unnatural biopolymers: lack of secondary structure in oligomeric carbopeptoids derived from a D-galacto-5-(aminomethyl) tetrahydrofuran-2-carboxylic acid

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Abstract

The efficient synthesis of a D-galacto-configured tetrahydrofuran amino acid from a seven-carbon lactone as a monomer for the generation of sequence-defined structured biopolymer mimics is described. Investigations into the characteristics of homooligomeric derivatives of this monomer indicate that they do not adopt well defined secondary structures. The unanticipated formation of a heterooligomeric derivative and investigations into its solution structure are also described.

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Publication details

The article was received on 13 Apr 2000, accepted on 14 Aug 2000 and first published on 18 Oct 2000


Article type: Paper
DOI: 10.1039/B002995P
Citation: J. Chem. Soc., Perkin Trans. 1, 2000,0, 3655-3665
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    Tetrahydrofuran amino acids—versatile building blocks for unnatural biopolymers: lack of secondary structure in oligomeric carbopeptoids derived from a D-galacto-5-(aminomethyl) tetrahydrofuran-2-carboxylic acid

    D. E. A. Brittain, M. P. Watterson, T. D. W. Claridge, M. D. Smith and G. W. J. Fleet, J. Chem. Soc., Perkin Trans. 1, 2000, 0, 3655
    DOI: 10.1039/B002995P

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