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Issue 4, 2000
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Rapid synthesis of 2-cyanobenzothiazole, isothiocyanate and cyanoformanilide derivatives of dapsone

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Abstract

New derivatives of the leprostatic drug dapsone are prepared by way of imino-1,2,3-dithiazoles obtained by condensation of aromatic primary bisamines, including dapsone, with 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt). Reactions, including microwave irradiation, initiated by nucleophilic attack at different sites of the dithiazole ring transform the bisiminodithiazoles into the symmetrical, and some unsymmetrical, title compounds.

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Publication details

The article was received on 02 Nov 1999, accepted on 08 Dec 1999 and first published on 03 Feb 2000


Article type: Paper
DOI: 10.1039/A908742G
Citation: J. Chem. Soc., Perkin Trans. 1, 2000,0, 563-566
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    Rapid synthesis of 2-cyanobenzothiazole, isothiocyanate and cyanoformanilide derivatives of dapsone

    T. Besson, J. Guillard and C. W. Rees, J. Chem. Soc., Perkin Trans. 1, 2000, 0, 563
    DOI: 10.1039/A908742G

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