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Issue 22, 2000
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Static and dynamic light scattering study on the association of some antidepressants in aqueous electrolyte solutions

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Abstract

The self-association of the antidepressant drugs amitriptyline, nortriptyline, doxepin and desipramine hydrochlorides in aqueous solution has been studied by static and dynamic light scattering at 298.15 K in the presence of added electrolyte (0.0–0.4 mol kg−1 NaCl). Self-assembly was by a closed association process, commencing at a well-defined critical concentration for all systems. Micelle properties determined from static and dynamic light scattering techniques as a function of electrolyte concentration were related to differences in the structure of the hydrophobe. The pair interaction potential between aggregates has been discussed in terms of the DLVO theory of colloidal stability.

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Publication details

The article was received on 04 Aug 2000, accepted on 14 Sep 2000 and first published on 18 Oct 2000


Article type: Paper
DOI: 10.1039/B006400I
Citation: Phys. Chem. Chem. Phys., 2000,2, 5175-5179
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    Static and dynamic light scattering study on the association of some antidepressants in aqueous electrolyte solutions

    P. Taboada, D. Attwood, J. M. Ruso, M. García and V. Mosquera, Phys. Chem. Chem. Phys., 2000, 2, 5175
    DOI: 10.1039/B006400I

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