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Issue 22, 2000
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Unusual RNA and DNA binding properties of a novel pyrrolidine–amide oligonucleotide mimic (POM)

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Abstract

A pentameric thymidyl pyrrolidine–amide oligonucleotide mimic (POM) was synthesised and shown to bind with very high affinity to complementary single stranded RNA and DNA, whilst exhibiting kinetic binding selectivity for RNA over DNA.

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Publication details

The article was received on 23 Aug 2000, accepted on 16 Oct 2000 and first published on 03 Nov 2000


Article type: Communication
DOI: 10.1039/B006903P
Citation: Chem. Commun., 2000,0, 2251-2252
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    Unusual RNA and DNA binding properties of a novel pyrrolidine–amide oligonucleotide mimic (POM)

    D. T. Hickman, P. M. King, M. A. Cooper, J. M. Slater and J. Micklefield, Chem. Commun., 2000, 0, 2251
    DOI: 10.1039/B006903P

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