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Issue 17, 2000
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Chiral organolithium species: determination of the rate of cyclization and extent of racemization

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Abstract

The rate of intramolecular carbolithiation onto an unactivated alkene to give a six-membered ring has been determined and follows first order kinetics with a half life of ∼90 min at 23 °C; this allows significant racemization using a chiral organolithium species, although good levels of optical purity are obtained with a phenylthio-substituted alkene.

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Publication details

The article was received on 06 Jun 2000, accepted on 10 Jul 2000 and first published on 02 Aug 2000


Article type: Communication
DOI: 10.1039/B004519P
Citation: Chem. Commun., 2000,0, 1569-1570
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    Chiral organolithium species: determination of the rate of cyclization and extent of racemization

    I. Coldham and G. P. Vennall, Chem. Commun., 2000, 0, 1569
    DOI: 10.1039/B004519P

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