Jump to main content
Jump to site search

Issue 16, 2000
Previous Article Next Article

Functional analysis of Phe605, a conserved aromatic amino acid in squalene–hopene cyclases

Author affiliations

Abstract

Incubation of squalene with the site-directed mutant F605A of squalene–hopene cyclase from Alicyclobacillus acidocaldarius yielded many triterpenes consisting of the 6/6/5-fused tri-, 6/6/6/5-fused tetra-, and 6/6/6/6/5-fused pentacyclic skeletons, the function of F605 being assignable for facilitating the ring expansion and for stabilizing the hopanyl C22-cation, possibly via cation-π interactions.

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 May 2000, accepted on 21 Jun 2000 and first published on 19 Jul 2000


Article type: Communication
DOI: 10.1039/B004129G
Citation: Chem. Commun., 2000,0, 1485-1486
  •   Request permissions

    Functional analysis of Phe605, a conserved aromatic amino acid in squalene–hopene cyclases

    T. Hoshino, M. Kouda, T. Abe and T. Sato, Chem. Commun., 2000, 0, 1485
    DOI: 10.1039/B004129G

Search articles by author

Spotlight

Advertisements