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Issue 15, 2000
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Synthesis and cross-coupling reactions of solid-supported alkylzinc reagents

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Abstract

Hydroboration of Wang-supported pent-4-enoic acid 1, followed by transmetallation with Et2Zn, gives a solid-supported zinc reagent, 2, which undergoes palladium-catalysed coupling with aryl iodides, to give the corresponding 5-arylpentanoic acids 3 in moderate to good yields, after cleavage from the resin using TFA.

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Publication details

The article was received on 10 May 2000, accepted on 15 Jun 2000 and first published on 07 Jul 2000


Article type: Communication
DOI: 10.1039/B003879M
Citation: Chem. Commun., 2000, 1401-1402
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    Synthesis and cross-coupling reactions of solid-supported alkylzinc reagents

    R. F. W. Jackson, L. J. Oates and M. H. Block, Chem. Commun., 2000, 1401
    DOI: 10.1039/B003879M

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