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Issue 24, 2000
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Pd-catalysed C–C macrocyclisation of a simple tripeptide: efficient total synthesis of K-13

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Abstract

The cyclic tripeptide K-13 has been prepared in 11 steps from commercially available starting materials (11% overall yield); the key step is the Pd-catalysed macrocyclisation of the zinc reagent prepared by selective insertion of zinc into the aliphatic C–I bond of the linear tripeptide 3, followed by Pd-catalysed macrocyclisation.

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Publication details

The article was received on 29 Sep 2000, accepted on 31 Oct 2000 and first published on 21 Nov 2000


Article type: Communication
DOI: 10.1039/B008078K
Citation: Chem. Commun., 2000,0, 2423-2424
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    Pd-catalysed C–C macrocyclisation of a simple tripeptide: efficient total synthesis of K-13

    M. Pérez-González and R. F. W. Jackson, Chem. Commun., 2000, 0, 2423
    DOI: 10.1039/B008078K

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