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Issue 8, 1999
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The mechanism of the metal ion promoted cleavage of RNA phosphodiester bonds involves a general acid catalysis by the metal aquo ion on the departure of the leaving group

Abstract

A series of uridine 3′-alkyl phosphates and 3′-aryl phosphates were synthesised and their cleavage was studied in the presence of Zn2+ aquo ions. A βlg value was determined for the Zn2+ promoted cleavage of both types of compounds. Comparison of the results obtained to those reported previously for the cleavage of the same substrates in the absence of metal ion catalysts suggests that the alkyl leaving group departs as an alcohol in the presence of metal ion catalysts. Furthermore, metal ion catalysts seem to enhance the departure. The aryl leaving group, in contrast, departs as an oxyanion.

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Article type: Paper
DOI: 10.1039/A903691A
Citation: J. Chem. Soc., Perkin Trans. 2, 1999, 1619-1626
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    The mechanism of the metal ion promoted cleavage of RNA phosphodiester bonds involves a general acid catalysis by the metal aquo ion on the departure of the leaving group

    S. Mikkola, E. Stenman, K. Nurmi, E. Yousefi-Salakdeh, R. Strömberg and H. Lönnberg, J. Chem. Soc., Perkin Trans. 2, 1999, 1619
    DOI: 10.1039/A903691A

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