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Issue 17, 1999
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Clean synthesis of α-bromo ketones and their utilisation in the synthesis of 2-alkoxy-2,3-dihydro-2-aryl-1,4-benzodioxanes, 2-amino-4-aryl-1,3-thiazoles and piperidino-2-amino-1,3-thiazoles using polymer-supported reagents

Abstract

An array of 2-alkoxy-2,3-dihydro-2-aryl-1,4-benzodioxane derivatives and 2-amino-1,3-thiazoles were prepared in high yield using a straightforward three-step and two- step sequence of polymer-supported reagents, respectively and other polymer-supported sequestering reagents without any chromatographic purification step. A key step involves clean and efficient bromination of acetophenones using polymer-supported pyridinium bromide perbromide (PSPBP) and subsequent cyclisation reaction.

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Article type: Paper
DOI: 10.1039/A905616E
Citation: J. Chem. Soc., Perkin Trans. 1, 1999, 2425-2427
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    Clean synthesis of α-bromo ketones and their utilisation in the synthesis of 2-alkoxy-2,3-dihydro-2-aryl-1,4-benzodioxanes, 2-amino-4-aryl-1,3-thiazoles and piperidino-2-amino-1,3-thiazoles using polymer-supported reagents

    J. Habermann, S. V. Ley, J. J. Scicinski, J. S. Scott, R. Smits and A. W. Thomas, J. Chem. Soc., Perkin Trans. 1, 1999, 2425
    DOI: 10.1039/A905616E

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