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Issue 4, 1999
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A rigid, cyclohexane-based polyamino-polyalcohol as a versatile building block for tailored chelating agents

Abstract

Selective, tailored chelators are of importance in medicine for the treatment of metal intoxication, or to stabilise metal cations in diagnostic radiopharmaceuticals and paramagnetic contrast agents. In this report, the co-ordination chemistry of polyamines, polyalcohols, and polyamino-polyalcohols is examined and some general prerequisites for a successful design of tailored chelators are summarised. The metal binding properties of 1,3,5-triamino-1,3,5-trideoxy-cis-inositol (taci), a rigid, cyclohexane-based polyamino-polyalcohol, are reviewed. Concepts for the design of selective chelators which are based on the taci structure are presented, and the potential of such ligands for medical applications is briefly discussed.

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Article type: Paper
DOI: 10.1039/A802638F
Citation: Chem. Soc. Rev., 1999,28, 239-249
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    A rigid, cyclohexane-based polyamino-polyalcohol as a versatile building block for tailored chelating agents

    K. Hegetschweiler, Chem. Soc. Rev., 1999, 28, 239
    DOI: 10.1039/A802638F

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