A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge Agelas sp. led to isolation of a trace (7.42 × 10–6% yield) cancer cell growth inhibitor (lung NCI-H460 GI50 0.77 µg m–1 to ovary OVCAR-3 GI50 2.8 µg ml–1) designated agelagalastatin 6; it is the first example of a natural product containing a digalactofuranosyl unit.
G. R. Pettit, J. Xu, D. E. Gingrich, M. D. Williams, D. L. Doubek, J. Chapuis and J. M. Schmidt, Chem. Commun., 1999, 915 DOI: 10.1039/A902380A
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