An intramolecular rhodium carbenoid C–H insertion approach to chiral isotwistanes. Synthesis of (–)-neopupukean-4,10-dione and (–)-neopupukean-10-one
Abstract
The first synthesis of a chiral neopupukeanane starting, from (R)-carvone and employing a double Michael reaction and a regioselective intramolecular rhodium carbenoid C–H insertion reaction as key steps, is described.