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Issue 16, 1998
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Enantioselectivity vs. kinetic resolution in antibody catalysis: formation of the (S) product despite preferential binding of the (R) intermediate

Abstract

Antibody 14D9, which catalyzes the stereoselective transformation of achiral enol ethers into the corresponding (S)-ketals, resolves a racemic mixture of structurally similar chiral enol ethers by selective conversion of the (R)-enol ether into the (R)-ketal, raising the possibility that the (S) transition state is preferencially stabilized by the antibody despite a better binding of the (R) intermediate.

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Article type: Paper
DOI: 10.1039/A802374C
Citation: Chem. Commun., 1998,0, 1759-1760
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    Enantioselectivity vs. kinetic resolution in antibody catalysis: formation of the (S) product despite preferential binding of the (R) intermediate

    D. Shabat, E. Keinan, D. Shabat, H. Shulman, H. Itzhaky and J. Reymond, Chem. Commun., 1998, 0, 1759
    DOI: 10.1039/A802374C

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