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Issue 16, 1998
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Enantioselectivity vs. kinetic resolution in antibody catalysis: formation of the (S) product despite preferential binding of the (R) intermediate

Abstract

Antibody 14D9, which catalyzes the stereoselective transformation of achiral enol ethers into the corresponding (S)-ketals, resolves a racemic mixture of structurally similar chiral enol ethers by selective conversion of the (R)-enol ether into the (R)-ketal, raising the possibility that the (S) transition state is preferencially stabilized by the antibody despite a better binding of the (R) intermediate.

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Article type: Paper
DOI: 10.1039/A802374C
Citation: Chem. Commun., 1998, 1759-1760
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    Enantioselectivity vs. kinetic resolution in antibody catalysis: formation of the (S) product despite preferential binding of the (R) intermediate

    D. Shabat, E. Keinan, D. Shabat, H. Shulman, H. Itzhaky and J. Reymond, Chem. Commun., 1998, 1759
    DOI: 10.1039/A802374C

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