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Issue 21, 1997
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Thermodynamically-controlled cyclisation and interconversion of oligocholates: metal ion templated ‘living’ macrolactonisation

Abstract

A series of ester-linked macrocyclic oligomers (dimer–pentamer) of cholates equipped with a variety of recognition and reporter elements has been prepared (a) by conventional irreversible chemistry, and (b) using methoxide-catalysed transesterification under reversible equilibrium conditions. Templating by metal ions under these equilibrium conditions is also demonstrated. These results demonstrate the feasibility of creating a dynamic combinatorial library of receptors.

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Article type: Paper
DOI: 10.1039/A703390G
Citation: J. Chem. Soc., Perkin Trans. 1, 1997,0, 3237-3254
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    Thermodynamically-controlled cyclisation and interconversion of oligocholates: metal ion templated ‘living’ macrolactonisation

    P. A. Brady and J. K. M. Sanders, J. Chem. Soc., Perkin Trans. 1, 1997, 0, 3237
    DOI: 10.1039/A703390G

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