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Issue 7, 1997
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Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an arylphosphonate linker for the generation of catalytic antibodies

Abstract

Syntheses of 6-methoxy-1-methyl-1,2,3,4-tetrahydroquinoline-3-methanol 10 and 1,2,3,5,6,10b-hexahydrobenzo[g]indolizine-6-methanol 34 are described. The aryl phosphonic acid 14, which can be used as a linker to a protein, is synthesised and coupled to the above alcohols. These haptens, when linked to a protein, are intended to generate antibodies able to catalyse cationic cyclisation reactions.

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Article type: Paper
DOI: 10.1039/A606968A
Citation: J. Chem. Soc., Perkin Trans. 1, 1997,0, 1017-1024
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    Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies

    C. González-Bello, C. Abell and F. J. Leeper, J. Chem. Soc., Perkin Trans. 1, 1997, 0, 1017
    DOI: 10.1039/A606968A

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