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Issue 6, 1997
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Phosphorimetric Determination of Indomethacin in PharmaceuticalFormulations


A simple, rapid and sensitive method for the determination of indomethacin was developed based on solid-surface room-temperature phosphorimetry. Phosphorescence emission was induced by the indomethacin hydrolysis reaction in a basic medium. Chromatography paper treated for background reduction was employed as a solid substrate. The use of four heavy-atom salts and sodium dodecyl sulfate was optimized to estimate an absolute limit of detection at the subnanogram level. A calibration curve with a linear dynamic range extending over two orders of magnitude (3.0 × 10 - 7 –1.0 × 10 - 4 mol dm - 3 ) was obtained. The recovery of the method (98.4 ± 6.8%) was tested using commercial formulations containing indomethacin as the only anti-inflammatory agent.

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Article type: Paper
DOI: 10.1039/A700309I
Citation: Analyst, 1997,122, 559-562
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    Phosphorimetric Determination of Indomethacin in Pharmaceutical Formulations

    A. F. Arruda and A. D. Campiglia, Analyst, 1997, 122, 559
    DOI: 10.1039/A700309I

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