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Issue 21, 1996
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Interaction of analogues of porphobilinogen with porphobilinogen deaminase

Abstract

2-Methylporphobilinogen 5 and 8,9-didehydroporphobilinogen 7 are only weak inhibitors of porphobilinogen deaminase (hydroxymethylbilane synthase). The phosphonate analogue 8 and 9-fluoroporphobilinogen 9 are good inhibitors, however, and also act as slow substrates (the first unnatural substrates known for this enzyme). The particularly strong inhibition shown by the fluoro analogue 9 is shown to be due to the slow regeneration of free enzyme once the compound has become covalently bound to it. This results in a sigmoidal dependence of rate vs.[substrate].

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Article type: Paper
DOI: 10.1039/P19960002643
Citation: J. Chem. Soc., Perkin Trans. 1, 1996,0, 2643-2649
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    Interaction of analogues of porphobilinogen with porphobilinogen deaminase

    F. J. Leeper and M. Rock, J. Chem. Soc., Perkin Trans. 1, 1996, 0, 2643
    DOI: 10.1039/P19960002643

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