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Issue 19, 1996
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Comparison of the substrate specificity of type I and type II dehydroquinases with 5-deoxy- and 4,5-dideoxy-dehydroquinic acid

Abstract

Syntheses of 5-deoxydehydroquinic acid and 4,5-dideoxydehydroquinic acid from quinic acid are described. These substrate analogues were tested against the mechanistically-distinct type I and type II dehydroquinases. The C-4 hydroxy group of the substrate is shown to be important for imine formation on the type I enzyme but appears not to contribute significantly to specificity on the type II dehydroquinase.

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Article type: Paper
DOI: 10.1039/P19960002371
Citation: J. Chem. Soc., Perkin Trans. 1, 1996,0, 2371-2377
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    Comparison of the substrate specificity of type I and type II dehydroquinases with 5-deoxy- and 4,5-dideoxy-dehydroquinic acid

    J. M. Harris, W. J. Watkins, A. R. Hawkins, J. R. Coggins and C. Abell, J. Chem. Soc., Perkin Trans. 1, 1996, 0, 2371
    DOI: 10.1039/P19960002371

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