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Issue 17, 1996
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Biosynthesis of porphyrins and related macrocycles. Part 45. Determination by a novel X-ray method of the absolute configuration of the spiro lactam which inhibits uroporphyrinogen III synthase (cosynthetase)

Abstract

A novel approach, involving X-ray analysis of a specifically designed racemate, in combination with correlations by circular dichroism, allows the absolute configuration of the spiro lactam 4 to be determined. The outcome is that the enantiomer of this lactam which strongly inhibits uroporphyrinogen III synthase (cosynthetase) has the R-configuration and the implications of this finding are briefly discussed.

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Article type: Paper
DOI: 10.1039/P19960002091
Citation: J. Chem. Soc., Perkin Trans. 1, 1996,0, 2091-2102
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    Biosynthesis of porphyrins and related macrocycles. Part 45. Determination by a novel X-ray method of the absolute configuration of the spiro lactam which inhibits uroporphyrinogen III synthase (cosynthetase)

    A. C. Spivey, A. Capretta, C. S. Frampton, F. J. Leeper and A. R. Battersby, J. Chem. Soc., Perkin Trans. 1, 1996, 0, 2091
    DOI: 10.1039/P19960002091

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