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Issue 8, 1996
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Taxol and taxane formation in plant cell culture

Abstract

The production of taxol, cephalomannine and baccatin III from a suspension cell culture of Taxus brevifolia has been investigated using HPLC and tandem mass spectrometry (MS/MS). Interference from other products in the cell culture medium led to development of an MS/MS assay based on negative ion desorption chemical ionization using [2H3]-labelled internal standards for measurements of these compounds at the level of 2–8 ng cm–3 of medium. The use of parent scans allowed the detection of a number of new taxanes for further study.

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Article type: Paper
DOI: 10.1039/P19960000845
Citation: J. Chem. Soc., Perkin Trans. 1, 1996,0, 845-851
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    Taxol and taxane formation in plant cell culture

    P. Heinstein, J. Zhou, M. Wang, Y. Liu, X. Chen, D. Chen, S. H. Hoke, R. G. Cooks and C. Chang, J. Chem. Soc., Perkin Trans. 1, 1996, 0, 845
    DOI: 10.1039/P19960000845

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