SCHEDULED MAINTENANCE
The interaction of various substrate analogues with 5-aminolaevulinic acid dehydratase (porphobilinogen synthase) from Bacillus subtilis is studied kinetically and by electrospray mass spectrometry; 5-chlorolaevulinic acid is shown to be a non-specific alkylating agent but 5-amino-3-thialaevulinic acid is a potent mechanism-based inactivator.
D. Appleton and F. J. Leeper, Chem. Commun., 1996, 303 DOI: 10.1039/CC9960000303
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