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Issue 8, 1996
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Sol–gel-based amperometric glucose biosensor incorporating an osmium redox polymer as mediator

Abstract

A novel amperometric biosensor for the determination of glucose was constructed by first immobilizing glucose oxidase and an osmium redox polymer, [Os(bpy)2(PVP)10Cl]Cl, on the surface of a glassy-carbon electrode, followed by coating with a sol–gel film derived from methyltriethoxysilane. The redox potential of this electrode was found to be +247 mV versus Ag/AgCl, and glucose could therefore be determined amperometrically at +400 mV versus Ag/AgCl. The concentration range of linear response, slope of linear response and LOD were 2.0–31 mmol l–1, 44.5 nA mmol–1 l and 0.5 mmol. l–1, respectively. Although L-ascorbate was electrooxidizable at this potential, uric acid and paracetamol were both found not to interfere.

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Article type: Paper
DOI: 10.1039/AC9963300271
Citation: Anal. Commun., 1996,33, 271-273
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    Sol–gel-based amperometric glucose biosensor incorporating an osmium redox polymer as mediator

    T. Park, E. I. Iwuoha, M. R. Smyth and B. D. MacCraith, Anal. Commun., 1996, 33, 271
    DOI: 10.1039/AC9963300271

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