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Issue 12, 1995
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Selective formation of hydrogen bonded cocrystals between a sulfonamide and aromatic carboxylic acids in the solid state

Abstract

Co-grinding sulfadimidine [4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide] with several aromatic carboxylic acids in the solid state produces 1 : 1 hydrogen bonded cocrystals which are identical to those obtained from reaction between the components in solution. The kinetics of solid state formation of selected cocrystals have been measured using X-ray powder diffraction. Sulfadimidine selectively cocrystallizes with 2-aminobenzoic acid when the latter is present in binary mixtures of acids. Solid state reaction of the cocrystal sulfadimidine·2-hydroxybenzoic acid with 2-aminobenzoic acid results in elimination of 2-hydroxybenzoic acid and formation of the cocrystal sulfadimidine·2-aminobenzoic acid.

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Article type: Paper
DOI: 10.1039/P29950002213
Citation: J. Chem. Soc., Perkin Trans. 2, 1995, 2213-2216
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    Selective formation of hydrogen bonded cocrystals between a sulfonamide and aromatic carboxylic acids in the solid state

    M. R. Caira, L. R. Nassimbeni and A. F. Wildervanck, J. Chem. Soc., Perkin Trans. 2, 1995, 2213
    DOI: 10.1039/P29950002213

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