Synthesis of enantiomerically pure α-hydroxyaldehydes from the corresponding α-hydroxycarboxylic acids: novel substrates for Escherichia coli transketolase

Andrew J. Humphrey; Nicholas J. Turner; Raymond McCague; Stephen J. C. Taylor

doi:10.1039/C39950002475

skip RSC | ChemSpider | Feedback

Home > Journals > Journal of the Chemical... > Synthesis of enantiomer...

Authors & Referees | Librarians

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Journal of the Chemical Society, Chemical Communications

Issue 24, 1995

Journal Home | RSC Journals

Paper

Previous Article | Next Article

Synthesis of enantiomerically pure α-hydroxyaldehydes from the corresponding α-hydroxycarboxylic acids: novel substrates for Escherichia coli transketolase

Andrew J. Humphrey , Nicholas J. Turner , Raymond McCague and Stephen J. C. Taylor

J. Chem. Soc., Chem. Commun., 1995, 2475-2476

DOI: 10.1039/C39950002475

Please wait while Download options loads

Request Permissions

Abstract
Cited by
Related Content

Enantiomerically pure (R)-α-hydroxyaldehydes (>95% ee) are prepared from the corresponding α-hydroxyesters by silyl protection, reduction with diisobutylaluminium hydride, and finally deprotection under acidic conditions; subsequent coupling of these aldehydes with lithium hydroxypyruvate, catalysed by Escherichia coli transketolase, leads to novel optically pure triols.

Terms & Conditions|Privacy |Accessibility|ACAP Enabled

Journal of the Chemical Society, Chemical Communications

Synthesis of enantiomerically pure α-hydroxyaldehydes from the corresponding α-hydroxycarboxylic acids: novel substrates for Escherichia coli transketolase

Log in (Free Access)

Log in (Subscriber Access)

Articles By