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Issue 17, 1995
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Stereochemical studies on the proposed spiro intermediate for the biosynthesis of the natural porphyrins: determination by a novel X-ray method of the absolute configuration of the spirolactam which inhibits cosynthetase

Abstract

A novel X-ray analysis, combined with correlations by circular dichroism, has been used to establish the (R)-configuration at the stereocentre in that enantiomer of the spirolactam 4 which strongly inhibits uroporphyrinogen III synthase.

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Article type: Paper
DOI: 10.1039/C39950001789
Citation: J. Chem. Soc., Chem. Commun., 1995,0, 1789-1790
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    Stereochemical studies on the proposed spiro intermediate for the biosynthesis of the natural porphyrins: determination by a novel X-ray method of the absolute configuration of the spirolactam which inhibits cosynthetase

    A. C. Spivey, A. Capretta, C. S. Frampton, F. J. Leeper and A. R. Battersby, J. Chem. Soc., Chem. Commun., 1995, 0, 1789
    DOI: 10.1039/C39950001789

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