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Issue 4, 1995
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A universal solid-phase synthesis of branched oligoribonucleotides

Abstract

A novel branch-point adenosine monomer is synthesized which enables the routine solid-phase synthesis of branched oligoribonucleotides in the 5′ to 3′ direction, such that the sequences at the 2′ and 3′ positions of the branch-point adenosine can be of different lengths and base composition; the method can be easily scaled up to produce milligram amounts of branched oligoribonucleotides, which are readily purified by reversed-phase HPLC whilst partially protected.

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Article type: Paper
DOI: 10.1039/C39950000495
Citation: J. Chem. Soc., Chem. Commun., 1995,0, 495-497
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    A universal solid-phase synthesis of branched oligoribonucleotides

    M. Grøtli and B. S. Sproat, J. Chem. Soc., Chem. Commun., 1995, 0, 495
    DOI: 10.1039/C39950000495

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