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Issue 21, 1994
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Biosynthesis of vitamin B12: mechanistic studies on the transfer of a methyl group from C-11 to C-12 and incorporation of 18O

Abstract

The transfer of a methyl group from C-11 to C-12 in vitamin B12 biosynthesis is shown, by a crossover experiment involving [1,11,17-(CD3)3]-labelled precursors, to occur in an intramolecular fashion; it is found that in Pseudomonas denitrificans, unlike Propionibacterium shermanii, no exchange of the ring A acetate oxygen atoms occurs during formation of the corrin ring.

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Article type: Paper
DOI: 10.1039/C39940002507
Citation: J. Chem. Soc., Chem. Commun., 1994,0, 2507-2508
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    Biosynthesis of vitamin B12: mechanistic studies on the transfer of a methyl group from C-11 to C-12 and incorporation of 18O

    Y. Li, A. I. D. Alanine, R. A. Vishwakarma, S. Balachandran, F. J. Leeper and A. R. Battersby, J. Chem. Soc., Chem. Commun., 1994, 0, 2507
    DOI: 10.1039/C39940002507

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