[1,10,20-13C3]Uro'gen III is unambiguously synthesised for enzymic conversion into precorrin-4 isolated after aerial oxidation as two epimers of Factor IV, the 13C NMR spectra of which rigorously confirm the presence of a C-1 acetyl group in precorrin-4; attachment of the fourth methyl group at C-17 of precorrin-4 is also confirmed by related 13C-labelling experiments.
A. I. D. Alanine, K. Ichinose, D. Thibaut, L. Debussche, N. Patrick, J. Stamford, F. J. Leeper, F. Blanche and A. R. Battersby, J. Chem. Soc., Chem. Commun., 1994, 193 DOI: 10.1039/C39940000193
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