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Issue 2, 1994
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Biosynthesis of vitamin B12: use of specific 13C-labelling for structural studies on factor IV

Abstract

[1,10,20-13C3]Uro'gen III is unambiguously synthesised for enzymic conversion into precorrin-4 isolated after aerial oxidation as two epimers of Factor IV, the 13C NMR spectra of which rigorously confirm the presence of a C-1 acetyl group in precorrin-4; attachment of the fourth methyl group at C-17 of precorrin-4 is also confirmed by related 13C-labelling experiments.

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Article type: Paper
DOI: 10.1039/C39940000193
Citation: J. Chem. Soc., Chem. Commun., 1994,0, 193-196
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    Biosynthesis of vitamin B12: use of specific 13C-labelling for structural studies on factor IV

    A. I. D. Alanine, K. Ichinose, D. Thibaut, L. Debussche, N. Patrick, J. Stamford, F. J. Leeper, F. Blanche and A. R. Battersby, J. Chem. Soc., Chem. Commun., 1994, 0, 193
    DOI: 10.1039/C39940000193

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