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Issue 18, 1993
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Nitrile oxide cycloaddition of non-activated alkynes: a novel approach to the synthesis of neuroactive isoxazoles

Abstract

A general method for the unprecedented 1,3-dipolar cycloaddition of bromonitrile oxide to disubstituted non-activated alkynes provides a useful alternative route to the neuropharmacological tools AMPA and 4-methylhomoibotenic acid.

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Article type: Paper
DOI: 10.1039/P19930002151
Citation: J. Chem. Soc., Perkin Trans. 1, 1993, 2151-2152
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    Nitrile oxide cycloaddition of non-activated alkynes: a novel approach to the synthesis of neuroactive isoxazoles

    P. Pevarello, R. Amici, M. Colombo and M. Varasi, J. Chem. Soc., Perkin Trans. 1, 1993, 2151
    DOI: 10.1039/P19930002151

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