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Issue 16, 1993
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Biosynthesis of the polyether antibiotic monensin A: incorporation of a polyketide chain elongation intermediate

Abstract

Evidence that the polyether antibiotic monensin A is constructed by a processive strategy of polyketide assembly has been obtained by the specific incorporation of labelled 5-oxo-2,4-dimethylhexanoate, activated as an acetylcysteamine thioester, into the antibiotic in shake cultures of Streptomyces cinnamonensis: crucial to the successful incorporation are the presence of 2,6-O-dimethyl-β-cyclodextrin and a β-oxidation inhibitor during the fermentation.

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Article type: Paper
DOI: 10.1039/C39930001258
Citation: J. Chem. Soc., Chem. Commun., 1993,0, 1258-1260
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    Biosynthesis of the polyether antibiotic monensin A: incorporation of a polyketide chain elongation intermediate

    H. Patzelt and J. A. Robinson, J. Chem. Soc., Chem. Commun., 1993, 0, 1258
    DOI: 10.1039/C39930001258

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