Isolation and structure elucidation of novel hypotensive agents, niazinin A, niazinin B, niazimicin and niaziminin A + B from Moringa oleifera: the first naturally occurring thiocarbamates

Shaheen Faizi; Bina Shaheen Siddiqui; Rubeena Saleem; Salimuzzaman Siddiqui; Khalid Aftab; Anwar-ul-Hassan Gilani

doi:10.1039/P19920003237

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Journal of the Chemical Society, Perkin Transactions 1

Issue 23, 1992

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Isolation and structure elucidation of novel hypotensive agents, niazinin A, niazinin B, niazimicin and niaziminin A + B from Moringa oleifera: the first naturally occurring thiocarbamates

Shaheen Faizi , Bina Shaheen Siddiqui , Rubeena Saleem , Salimuzzaman Siddiqui , Khalid Aftab and Anwar-ul-Hassan Gilani

J. Chem. Soc., Perkin Trans. 1, 1992, 3237-3241

DOI: 10.1039/P19920003237

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Novel hypotensive principles, niazinin A 1, niazinin B 2, niazimicin 4 and niaziminin A and B 6+7, have been obtained from the ethanolic extract of the fresh leaves of Moringa oleifera, employing a bioassay-guided isolation procedure. Their structures have been elucidated through spectroscopic (including 2D NMR techniques) and chemical methods. These compounds are mustard oil glycosides which are very rare in Nature and are also the first examples of naturally occurring thiocarbamates.

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Shaheen Faizi
Bina Shaheen Siddiqui
Rubeena Saleem
Salimuzzaman Siddiqui
Khalid Aftab
Anwar-ul-Hassan Gilani

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Journal of the Chemical Society, Perkin Transactions 1

Isolation and structure elucidation of novel hypotensive agents, niazinin A, niazinin B, niazimicin and niaziminin A + B from Moringa oleifera: the first naturally occurring thiocarbamates

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