Mild and selective hydrolysis of aliphatic and alicyclic nitriles leading to carboxylic acids and amides was achieved under neutral conditions by an immobilized enzyme preparation from Rhodococcus sp. This method is particularly useful for the transformation of compounds containing other acid- or base-sensitive groups.
A. de Raadt, N. Klempier, K. Faber and H. Griengl, J. Chem. Soc., Perkin Trans. 1, 1992, 137 DOI: 10.1039/P19920000137
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