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Issue 3, 1992
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Modified substrates for tetrapyrrole biosynthesis: analogues of porphobilinogen showing unusual inhibition of porphobilinogen deaminase

Abstract

Syntheses are described of two analogues of porphobilinogen (PBG), a fluoro derivative 10 and a phosphonate 13, which are the first known unnatural substrates of PBG deaminase; when they act as inhibitors of the reaction of PBG, these compounds produce unusual sigmoidal kinetics, explained by their involvement as poor substrates in the particular mechanism of this enzyme.

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Article type: Paper
DOI: 10.1039/C39920000242
Citation: J. Chem. Soc., Chem. Commun., 1992,0, 242-244
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    Modified substrates for tetrapyrrole biosynthesis: analogues of porphobilinogen showing unusual inhibition of porphobilinogen deaminase

    F. J. Leeper and M. Rock, J. Chem. Soc., Chem. Commun., 1992, 0, 242
    DOI: 10.1039/C39920000242

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