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Issue 6, 1991
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Synthetic studies on the proposed spiro intermediate for biosynthesis of the natural porphyrins: the stereochemical probe

Abstract

The intermediacy of the spiro-pyrrolenine for biosynthesis of uro'gen III is supported by synthesis of both enantiomers of the spiro-lactam 6 followed by demonstration that cosynthetase, the enzyme which forms uro'gen III, is inhibited over twenty times more strongly by one enantiomer than by the other.

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Article type: Paper
DOI: 10.1039/C39910000384
Citation: J. Chem. Soc., Chem. Commun., 1991,0, 384-386
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    Synthetic studies on the proposed spiro intermediate for biosynthesis of the natural porphyrins: the stereochemical probe

    M. A. Cassidy, N. Crockett, F. J. Leeper and A. R. Battersby, J. Chem. Soc., Chem. Commun., 1991, 0, 384
    DOI: 10.1039/C39910000384

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