Determination of chlordiazepoxide by zinc or cadmium reduction in a continuous system followed by atomic absorption spectrometric detection

Abstract

The analytical possibilities of using simple unsegmented configurations including redox columns for the selective determination of organic compounds with atomic absorption spectrometric detection are discussed. A method based on reduction with cadmium or zinc was developed for the determination of chlordiazepoxide in pharmaceutical preparations. This drug can be determined in the range 2.0–25 µg ml^–1 with a relative standard deviation between 1.1 and 2.8% and a sampling frequency of 150 h^–1. The method is selective towards the reduction of the N-oxide group and permits the determination of chlordiazepoxide in the presence of other 1,4-benzodiazepines.