The analytical possibilities of using simple unsegmented configurations including redox columns for the selective determination of organic compounds with atomic absorption spectrometric detection are discussed. A method based on reduction with cadmium or zinc was developed for the determination of chlordiazepoxide in pharmaceutical preparations. This drug can be determined in the range 2.0–25 µg ml–1 with a relative standard deviation between 1.1 and 2.8% and a sampling frequency of 150 h–1. The method is selective towards the reduction of the N-oxide group and permits the determination of chlordiazepoxide in the presence of other 1,4-benzodiazepines.
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