Bridged systems via radical cyclisations: synthesis of chiral bicyclo[3.3.1]nonanes by sequential inter- and intra-molecular radical Michael addition

Abstract

A stereoselective synthesis of functionalised chiral bicyclo[3.3.1]nonanes, by a sequential inter- and intra-molecular radical Michael addition of the radical (4), generated in two steps from (S)-carvone (1), in the presence of an excess radicophile (5), is described.