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Issue 16, 1988
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Biosynthesis of vitamin B12: when is the 12β-methyl group of the vitamin generated by acetate decarboxylation?

Abstract

The 12-methyl analogue (13) of the aromatised form of precorrin-3(5) has been prepared by enzymic C-methylation of 12-decarboxy-uro'gen-III (2) and is used for incorporation experiments which indicate that decarboxylation of the 12-acetate residue in B12-biosynthesis occurs after C-17 methylation.

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Article type: Paper
DOI: 10.1039/C39880001117
Citation: J. Chem. Soc., Chem. Commun., 1988,0, 1117-1119
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    Biosynthesis of vitamin B12: when is the 12β-methyl group of the vitamin generated by acetate decarboxylation?

    F. Blanche, S. Handa, D. Thibaut, C. L. Gibson, F. J. Leeper and A. R. Battersby, J. Chem. Soc., Chem. Commun., 1988, 0, 1117
    DOI: 10.1039/C39880001117

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